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MRC-Holland MLPA kitek

MRC Holland RBG Digital use 

MRC-Holland and MLPA® 

MLPA® (Multiplex Ligation-dependent Probe Amplification) is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be used to determine if a known mutation is present in the DNA or to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and exclusive manufacturer of MLPA assays, offers more than 400 different MLPA panels used for DNA copy number quantification, mutation identification, and DNA methylation status.


MLPA protocol 2


Popular MLPA applications 

  1. Predisposition to Cancer
    • BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, APC, MMR, NF1 
  2. Neuromuscular Disorders
    • SMA, DMD, CMT1
  3. Intellectual Disability
    • microdeletion, PWS/AS, FMR1/AFF2, MECP2, Sotos, WBS, SHOX, aneuploidy
  4. Solid Tumours
    • Gliomas, MMR, Neuroblastoma, TP53, Breast
  5. Methylation profiling
  • Prader-Willi / Angelman syndrome, Fragile X, Beckwith-Wiedemann Syndrome


Advantages and features of MLPAMLPA kit photo2

Examine up to 60 targets per reaction

Only 50ng of DNA is required per reaction

MLPA detects a short sequence of 60-80 nucleotides

Detection of single exon deletions and duplications

Detection of targeted point mutations

One simple protocol for  >400 applications

Results available within 24 hours

Limited lab equipment required: only a thermocycler and a sequence type electrophoresis system

User-friendly, reliable, and free data analysis software, Coffalser.NetTM


Visit the MLPA website to:

  • Search for genes, and chromosomal regions of interest  to find all related MLPA products
  • Explore the MLPA procedure to learn how to do MLPA
  • Get MLPA support by viewing education, workshop, and troubleshooting material
  • Stay up to date with current MLPA news


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