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BioLector

Microbioreactor for high-throughput fermentations with the online monitoring of biomass, pH, DO, and fluorescences.

The BioLector II measures the most common fermentation parameters online while running a cultivation. Additionally, the bench top microbioreactor controls the shaking speed, the temperature inside the cultivation chamber, and the humidity.

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Leírás

Real time culture monitoring on a parallel scale

Working Principle

The micro fermentation system is based on standard disposable microtiter plate formats and operates with non-invasive, optical sensors. Due to the continuous and rigorous shaking during the optical measurements and during the entire experiment, it is ideally suited for aerobic and anaerobic cultures.

Optional Modules

If a high or very low oxygen level is required, the system can be easily upgraded with additional modules, for example for CO2-enriched aeration, or anaerobic conditions.

By adding one of these modules the microbioreactor maintains all existing basic features. An upgrade with multiple modules in one system is possible.

/// Gas Modules

O2 up regulating module for the up-regulation of oxygen up to 35 %
O2 down regulating module for the down-regulation of oxygen down to 2 %
CO2 up regulating module for fermentation with a CO2-controlled gas atmosphere
Anaerobic cultivation set for cultivating under anaerobic conditions.

/// Fluorescence Modules

LED / filter module for fluorescence measurements for wavelengths between 365 nm - 950 nm
Low pH filter module for low pH measurements in the range of 4-6.

Up to three additional fluorescence modules can be added; in total, six different ones fit into the system.

Műszaki specifikációk

Advantages

Real-time kinetics of 48 parallel fermentations
Microfermentation in standard MTP format
Combined with a robotic liquid handling module:
- Batch and fed-batch
- Media preparation
High-throughput and easy automation
Broad range for biomass detection (equivalent to up to 250 OD600, 50 g/L CDW, measured with E. coli)
Biomass measurement is online and does not require dilution
Low pH measurements in the range of 4-6
Small volume (800-2400 μL)
No edge effects
Continuous shaking operation (no artifacts)
Defined mass transfer conditions
Reliable scale up to benchtop fermenters
Industry leading data analysis software
Fast and easy data analysis included
A valuable tool for PAT and QbD
System upgradable to BioLector Pro with microfluidic plate