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Bővebb információt és részletes leírást talál a gyártó weboldalán: CellXpress.ai Automated Cell Culture System | Molecular Devices
This revolutionary solution can give your lab the confidence in experimental outcomes to make key decisions sooner, achieve milestones faster, and get to clinic earlier—with lower attrition rates. All of it backed with the assurance of a full event log to confirm on-time feedings and critical task execution with complete digital microscopy records.
Total control over demanding feeding and passaging schedules reduces hands-on time in the lab.
3D cell culture workflow using automated platforms:
Key Features:
Actionable imaging and turnkey protocols for reliable media exchange, monitoring, and passaging. Automated cell culture and image analysis workflows run 24/7 – even when your lab is closed.
A unified software environment makes it easy to develop traceable and reproducible cell cultures specific to your desired assay endpoint.
Answer critical questions sooner easily identifying outliers at the well, plate, or experiment level to help detect variability sources. Save reagents by removing these plates or wells from downstream processing early in the drug discovery process.
Improve productivity and optimize hands-on time with image-based, deep-learning decision-making. Remove variability, maintain sterility, and increase confidence in success with automated cell handling.
Reliable and consistent automation speeds the development process. Real-time feedback alerts users to milestones or events and generates automated tasks to resolve them.
Solve complex image analysis problems utilizing advanced artificial intelligence (AI) to transform images into results. User-friendly workflows help you get answers faster from 2D, 3D, and time lapse experiments.
Bővebb információt és részletes leírást talál a gyártó weboldalán: CellXpress.ai Automated Cell Culture System | Molecular Devices
Amennyiben segítségre van szüksége, vagy árajánlatot szeretne kérni, legyen szíves használja az ÁRAJÁNLATOT, INFORMÁCIÓT KÉREK! gombot és munkatársunk hamarosan felveszi önnel a kapcsolatot!
Incubator | |
---|---|
Capacity (choose) |
44 plate max – 2 rack capacity 154 plate max – 7 rack capacity |
Decontamination | Automated hydrogen peroxide decontamination |
Environmental control | CO2, temperature, and humidity control |
Imager | |
Objectives | 2X through 40X objectives available |
Imaging modes | TL and up to 6 FL channels |
Acquisition mode | Time lapse, Z-stack, optional Digital Confocal* |
LED light source | 7 LEDs ranging from 365 to 730nm |
Available filter cubes | DAPI, FITC, TRITC, TxRed, Cy5, Cy7, CFP, YFP |
Environmental control | Temperature and CO2 control |
Camera | 24 megapixel camera |
Acquisition speed | Rapid whole plate acquisition |
Liquid handler | |
Pipette head | Span 8 |
Deck locations | 9 positions: plate cooling, heating, and tilting |
Cell culture media | Heated and cooled positions for low-volume and bulk media |
Decontamination | Automated on-deck UV decontamination |
Waste | |
Liquid waste | 10L liquid waste capacity with volume tracking |
Solid waste | 60L solid waste capacity with automated lid |
System | |
Transfer ports | 2 plate transfer ports |
Enclosure | HEPA filtered with anti-clog sensor |
On-system display | 15” touchscreen display |
External workstation | 10 Tb workstation with 27” LED monitor |
Size | 2,250 mm W x 954 mm D x 2,155 mm H |
Weight | 1,042 kg / 1,100 kg |
Power consumption | 2000W max, 2ea 10A lines |
Certifications | CSA, CE |
Software | |
Cell culture protocol manager | Pre-defined and user-defined protocols |
Experiment manager | At-a-glance experiment manager |
Cell journey | Phase-based cell journey with film-strip viewer |
Decision making | Rule-based decision making to advance, stop cell culture |
System dashboard | At-a-glance dashboard informs the user of immediate or upcoming actions needed |
User alerts | Configurable alerts keep the user informed about the state of the cell culture |
Three-dimensional (3D) cell models are physiologically relevant and more closely represent tissue microenvironments, cell-to-cell interactions, and biological processes that occur in vivo. Now you can generate more predictive data by incorporating technologies like the ImageXpress system with the integrated 3D Analysis Module in MetaXpress® software. This single interface will enable you to meet 3D acquisition and analysis challenges without compromise to throughput or data quality, giving you confidence in your discoveries.
Learn more about 3D cell imaging and analysis
One common way of culturing cells in three dimensional space is through the use of extracellular matrix-based hydrogels, such as Matrigel. Cells are grown in an extracellular matrix (ECM) to mimic an in vivo environment. Differences between Matrigel and 2D cell cultures can be readily seen by their different cell morphologies, cell polarity, and/or gene expression. Hydrogels can also enable studies on cell migration and 3D structure formation, such as endothelial cell tube formation in angiogenesis studies.
Disease model systems range in complexity and scale from simple 2D cell cultures to complex model organisms. While model organisms offer in vivo context, they are often costly and may not represent human biology. On the other hand, while traditional 2D cell culture systems have been used for many years, they have limitations in representing the complex three-dimensional structure and cellular interactions found in living tissues. As a result, 3D cell cultures have emerged as an attractive model system for disease modeling.
Learn more about disease modeling
For every drug that makes it to the finish line, another nine don’t succeed. This alarming failure rate can be traced to reliance on 2D cell cultures that don’t closely mimic complex human biology, often leading to inaccurate predictions of a drug’s potential and extended drug development timelines.
Learn More about drug discovery & development
Live cell imaging is the study of cellular structure and function in living cells via microscopy. It enables the visualization and quantitation of dynamic cellular processes in real time.
Live cell imaging encompasses a broad range of biological applications, from long-term kinetic assays to fluorescently labeling live cells.
Learn how cellular processes are analyzed using methods featured in our application notes
Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about instrumentation and software that facilitate cancer research using, in many cases, biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.
Organ-on-a-chip (OoC) is a technology that uses microfabrication techniques to create miniature models of biological organs, such as the lung, heart, or gut, on a chip-sized device. These microfabricated devices are made up of living cells that are grown on a microscale platform and mimic the structure and function of the organ they represent. The cells are typically arranged in a way that mimics the native three-dimensional structure of the organ and is perfused with fluids, such as blood or air, to represent the physiological environment of the organ.
Organoids are three-dimensional (3D) multi-cellular microtissues that are designed to closely mimic the complex structure and functionality of human organs. Organoids typically consist of a co-culture of cells which demonstrate a high order of self-assembly to allow for an even better representation of complex in vivo cell responses and interactions, as compared to traditional 2D cell cultures.
Spheroids are multi-cellular 3D structures that mimic in vivo cell responses and interactions. They can be highly reproducible and to be scaled for high-content screening. Compared with adherent cells grown in 2D monolayers, 3D growth conditions are believed to more closely reflect the natural environment of cancer cells. Acquiring measurements from these larger structures involve acquiring images from different depths (z-planes) within the body of the spheroid and analyzing them in 3D, or collapsing the images into a single 2D stack before analysis.
Pluripotent stem cells can be used for studies in developmental biology or differentiated as a source for organ-specific cells and used for live or fixed cell-based assays on slides or in multi-well plates. The ImageXpress system has utility in all parts of the stem cell researcher’s workflow, from tracking differentiation, to quality control, to measuring functionality of specific cell types.
Learn more about stem cell research
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It is a growing concern in our world today as we are exposed to more and more chemicals, both in our environment and in the products we use.
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