High-resolution for High-density Microarrays:
The GenePix® 4300/4400 Microarray Scanner and GenePix® Pro Microarray Analysis Software have been designed to work together as a complete, integrated platform. The seamless communication between scanner and software ensures unmatched efficiency for data acquisition and analysis, as well as for real-time scanner performance monitoring. Optional Acuity® Microarray Informatics Software completes the package, offering database storage, clustering algorithms, advanced statistics and visualizations.
Maximum scan area
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22 x 75 mm
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Maximum resolution
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4300A: 5 µm, 4400A: 2.5 µm
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Scan mode and order
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Sequential; fully user-configurable scan order
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Excitation
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Up to 4 lasers (all internal); 488 nm, 53 nm, 635nm
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Laser Settings
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User selectable, from 5-100% (1% increments)
Emission filters: 16 positio user-accessible filter wheel
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Detector
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Photomultiplier tube (PMT) automatic and manual gain adjustment settings
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Focus offset
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Adjustable between -50 to +200 μm (1 μm increments)
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Optics
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Non-confocal
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Emission filters
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See Configurations section below
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Scanning method
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Sequential
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Scan time:
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4 minutes per channel, 10 μm resolution, full scan area
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Pixel Resolution
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4300A-Adjustable from 5-100 μm, 4400A-Adjustable from 2.5-100 μm
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Digital Resolution
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16-bit
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Image Format
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Single-image or multi-image TIFF
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Dynamic Range
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Four orders of magnitude at SNR > 3
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Rotational Uniformity
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Less than ±4% non-uniformity
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Image Type
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Single- or multi- image TIFF
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Barcode Reading
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Integrated hardware barcode reader; all common 1D and 2D barcodes
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General Specifications |
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Dimensions (cm)
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43 cm (16.9") x 65 cm (25.6") x 34 cm (13.4") (WxDxH)
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Weight
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45 kg (99 lbs)
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Power Supply
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85 to 264 VAC (110 to 340 VDC) universal voltage input
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Line Frequency
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50-60 Hz
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Power
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150W
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Fuse
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2.0 A slow. 5 x 20 mm
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Dimensions (in)
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16.9 (W) x 13.4 (H) x 25.6 (D)
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Computer interface
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USB 2.0
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Although the analysis of the full proteome has not yet been achieved, rapid progress is being made with microarrays in the field of proteomics. Proteomes exhibit large and dynamic complexity; the number for distinct proteins in mammals will certainly exceed the number of genes, requiring the right technology to be in place for the analysis. The flexibility of the GenePix system, and especially the high-throughput capabilities of the GenePix® SL50 Automated Slide Loader, provides adequate tools to researchers.
Directed at the genome sequence itself, microarrays have been used to identify novel genes, binding sites of transcription factors, changes in DNA copy number, and variations from a baseline sequence, such as in emerging strains of pathogens or complex mutations in disease-causing human genes.
The use of high-density microarrays has impacted the measurement of transcript levels to study complex diseases. With the latest development of microarray technology, it is now possible to quantify transcript levels globally and to integrate such data with information relating to disease. Microarrays based transcriptomics enables mapping a critical genomic region for a disease using affected and unaffected individuals and then pinpointing the responsible gene by identifying differentially expressed genes in the critical region.
The gene carries the basic unit of information, but this information has an impact only once it is properly programmed by the epigenome. The DNA methylation pattern is cell type specific and correlates with chromatin structure. DNA microarrays are being utilized to identify methylation patterns, and the GenePix automation solution allows the researcher to identify these patterns faster.
The creativity and broad applicability of microarray-based research has no limits and is demonstrated by the vast variety of different microarray applications to conduct large-scale quantitative analysis. With the GenePix® Microarray Scanner System you have the most flexible solution and freedom in your research.
Product |
Part Number |
GenePix 4300A Scanner configurable with GenePix Pro, Includes 532nm green laser and 635nm red laser
|
GENEPIX 4300
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GenePix 4400 Scanner configurable with GenePix Pro, Includes 532nm green laser and 635nm red laser
|
GENEPIX 4400
|
GenePix Pro Software v7 license | 5004757 |
AcuityMicroarray Informatics Software | ACUITY PTO |
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