The software includes a wealth of analysis tools including 24 cursor pairs for regions of interest search, graph plotting tools such as I-V plot and histogram, and more.
The membrane testwindow displays up to eight channels simultaneously, making it easier to control multiple channels.
A simple continuous "chart-recorder" useful for monitoring single channel events, minis, and other spontaneous activities. Protocol-editor-style epochs and program digital or analog outputs can be executed.
This tool automatically calculates amplitude, area under the curve, half-width, decay and rise time, decay and rise slope, coastline of spike, and paired pulses.
This feature automatically detects and analyzes amplitude, APD90, rise and decay time, rise and decay slope, peak-to-peak frequency and time, and more.
Macros for batch analysis eliminates the need to define parameters for every data set. Saved macros can be applied to multiple data sets for automatic analysis.
Operating system
Minimum: Windows 7 Pro (32-bit)**
Recommended: Windows 10 Pro (32- or 64-bit)**
CPU
Minimum: PC with 2 GHz processor
Recommended: PC with 2.0 GHz (or faster) Duo Processor
RAM
Minimum: 1.2 GB RAM
Recommended: 4 GB or higher
Display
Minimum: 1440 x 900 display
Recommended: 1920 x 1080 display or higher
Ports
Minimum: 1 USB 1 port (for security key dongle), 1 USB 2.0 port (for Digidata digitizers)
Recommended: 3 USB 2.0 ports
**We only support Professional, Enterprise, and Ultimate editions but not Home edition.
Ion channels are pore proteins that are involved in a large variety of physiological processes. Basic research in the ion channel field furthers the understanding of ion channel function as well as their roles within cellular pathways and processes. Single-channel research helps with elucidating the mechanisms underlying ion channel function on a single-molecule level. Whole-cell and perforated patch clamp recordings are typically used to investigate the action of modulators on entire populations of ion channels in the membrane of a cell.
Ion channels are involved in many cell pathways and understanding the function of ion channels in response to changes in membrane potential or the presence or absence of other molecules is important in order to understand exactly how ion channels participate in normal and abnormal biological processes such as cell differentiation and migration, disease states, neuronal communications, etc.
Ion channels play a role in many diseases, including hypertension, cardiac arrhythmias, gastrointestinal, immune and neuromuscular disorders, pathological pain and cancer. By understanding the exact role that ion channels play in a particular disease, researchers might be able to find a way to affect the ion channel in such a way as to alter the course of the disease. Learn more.
A critical part of drug discovery involves safety assessments, such as hERG testing, in order to eliminate any compounds with potential safety concerns. Conventional patch clamp has played an important role in collecting evidence for the absence of side effects before submission of a drug candidate to regulatory authorities. Even if automated electrophysiology has shifted safety testing to earlier stages in the drug discovery process, follow-up with conventional patch clamp is an essential step in the workflow.
Compatible instruments
Digidata 1550B 8-Channel Digitizer
Digidata 1440A 16-Channel Digitizer
MiniDigi 1B Two-Channel Digitizer
Axoclamp 900A Microelectrode Amplifier
Axopatch 200B Microelectrode Amplifier
MultiClamp 700B Microelectrode Amplifier
Most BNC-telegraphed amplifiers also supported*
*Supports all previous versions in a model line.
Forgalmazott termékeink gyártói - keressen gyártó szerint a logóra kattintva